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Hepatocellular carcinoma (HCC) is the fifth most common cancer and, ranking as [4] the second most frequent [1] cause of tumor-related deaths worldwide. In 2019, the American Cancer Society estimated that the number of new cased of liver cancer and cancer deaths [3] in the United States would will [1] reach 42,030 and, accompanied by 31,780 respectively cancer deaths [3] . Prognosis for Cuttently patients with early-stage HCC have a good prognosis after surgical treatment is most likely to be good [4]. However, due to the insidious onset and early metastasis of HCC, the majority of patients cannot beare diagnosed untilin the advanced stage, when the window and lose the chance [4] of surgery is gone. Therefore, it is of great significance to find novel therapeutic biomarkers and targets for HCC diagnosis. [3]

          Uubiquitin-specific [1] protease 11 (USP11), located on human chromosome 11q12-13, is a type of [2] structure-specific metallonuclease involved in DNA replication, DNA synthesis, and DNA [3] damage repair, non-homologous end-joining (NHEJ) and homologous recombination (HR). In this regard Thus [3], USP 11 is essential to for the maintainenance of genomeic [4] stability. Previous studies have shown that USP 11 is abnormally expressed in lung, breast, gastric, prostate, and other types of cancer, and it [2] is closely correlated with the occurrence and development of tumors. It ishas been [2] reported that USP 11 is highly expressed in liver cancer, but its role in liver cancer and specific molecular mechanisms needremain [3] to be further elucidated.

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